Regulation of vascular smooth muscle cell differentiation
نویسندگان
چکیده
منابع مشابه
Redox regulation of vascular smooth muscle cell differentiation.
Experiments were performed to determine the role of reactive oxygen species (ROS) in regulating vascular smooth muscle cell (VSMC) phenotype. After quiescence, cultured human VSMCs increased their expression of differentiation proteins (alpha-actin, calponin, and SM1 and SM2 myosin), but not beta-actin. ROS activity, determined using the H(2)O(2)-sensitive probe dichlorodihydrofluorescein (DCF)...
متن کاملVascular smooth muscle cell differentiation-2010
Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discove...
متن کاملNox 4 regulation of vascular smooth muscle cell differentiation marker gene expression.
Vascular smooth muscle cells (VSMCs) undergo phenotypic switching in response to vascular injury. A hallmark feature of VSMC phenotypic switching is altered expression of VSMC-selective genes that define the contractile phenotype, including SM -actin, SMC myosin heavy chain (SM-MHC), Calponin, SM22 , and H-caldesmon.1 Although expression of no single marker is specific for SMC lineage, SM-MHC a...
متن کاملMolecular regulation of vascular smooth muscle cell differentiation in development and disease.
The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well as how these mechanisms/processes are altered in vascular injury or disease. A major challenge in understanding differentiation of the vascula...
متن کاملThe regulation of vascular smooth muscle cell apoptosis.
Apoptosis describes the morphological changes that identify a specific form of regulated cell death. Over recent years, the importance of either aberrant onset or suppression of apoptosis within tissues has become apparent and is associated with the development of several terminal diseases. Here we describe the relevance of apoptosis to the maintenance of vascular homeostasis. Specifically, we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2007
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2007.03.001